1Since this question is getting a lot of attraction, I decided to post what worked for me
2
3Remove Specific User's Specific Reaction
4
5// Channel = the channel object of the message's original channel
6// MessageID = ID of the message, if hard coding, put around quotations eg: "1234"
7
8const msg = await channel.messages.fetch(MessageID);
9
10msg.reactions.resolve("REACTION EMOJI,
11REACTION OBJECT OR REACTION ID").users.remove("ID OR OBJECT OF USER TO REMOVE");
12Note: If using an older version of discord.js, simply replace channel.messages.fetch with channel.fetchMessage