1>>> df.fillna(0)
2    A   B   C   D
30   0.0 2.0 0.0 0
41   3.0 4.0 0.0 1
52   0.0 0.0 0.0 5
63   0.0 3.0 0.0 4
71When inplace = True , the data is modified in place, which means it will return nothing and the dataframe is now updated. When inplace = False , which is the default, then the operation is performed and it returns a copy of the object. You then need to save it to something.